By analyzing historical strong earthquake activity,tectonic activity background,regional strain accumulation and anomaly character on regional seismicity before the Nilka-Gongliu Ms6.0 earthquake on November 1,2011 and the Xinyuan-Hejing Ms6.6 earthquake on June 30,2012,the article researches the mid-and short-term anomaly character on seismicity before the two Ms 6.0 earthquakes.The result shows that moderately strong earthquake activity in the northern Tianshan mountains appeared accelerated since June,2011,and entered into the strain energy release stage.There are obvious mid-term anomalies such as Ms6.0 earthquake quiescence and broken,grouping activity and space migration of moderately strong earthquakes,seismic belt and gap etc.before the 2011 Nilka-Gongliu Ms6.0 earthquake and the 2012 Xinyuan-Hejing Ms6.6 earthquake.There appeared M > 4.0 earthquake gap and imminent earthquake with the magnitude 5.0 before the two earthquakes,and the time intervals between the imminent earthquakes and the mainshocks were both 14 days or so,and which shows the clear abnormal images and mid-and short-term anomaly character.