The formed age of basalt from Daxizhuang, Jiaozhou is between Mesozoic and Cenozoic and this offers a good opportunity to trace the deep processes and the lithospheric evolution. Based on contrastive studies on the isotopic data of the Mesozoic-Cenozoic basic rocks from eastern China, it is suggested that the Mesozoic isotopic enriched lithospheric mantle had transformed into Cenozoic "juvenile" ocean-like ones in eastern North China Craton. From NNW to SSE, contribution of materials derived from subducted slab of the Pacific plate progressively increased in the asthenospheric mantle source from which the Cenozoic basalts derived with little trail of enriched lithospheric mantle. Transformation of the lithospheric mantle also took place in eastern south China, a similar process to that in eastern North China Craton with the dominant mode being metasomatism of melt instead of delamination.