In this paper, the REE compositions of metallic sulfides and hydrothermal quartz from Mengya’a Pb-Zn deposit were determined by ICP-MS. The studies show that pyrrhotite, chalcopyrite, sphalerite and galena are somewhat different in REE amount, but they all have the distribution patterns of rightly-oblique LREE enrichment type. According to the Eu anomaly, these metallic sulfides can be divided into 3 groups, and the Eu anomalies are mainly caused by the transformation of physical and chemical environment in the ore-forming process and the mass crystallization of calcite.