color: #222222">Derni massive sulfide Cu(Zn-Co) deposit is mainly wrapped by ophiolite in East Kunlun Mountains, and 8 massive sulfide ores give an isochronal age of (295.5±7.2) Ma by Re-Os isotope. According to the texture and structure of the ores, mineral compositions and various geochemistry data, the genesis of Derni Cu(Zn-Co) ore deposit can be summarized as submarine exhalation-sedimentary mineralization and experienced later hydrothermal superimposition, which is similar to Cyprus-type VMS deposit by tectonic setting and mineral compositions.