TIMS or MC-ICP-MS can be employed to measure stable strontium isotopes, and the ratios are expressed as δ88/86 Sr. Variations in δ88/86 Sr in nature range from -1.73‰ to 0.66‰. The factors affecting strontium fractionation are indistinct. At present the applications of stable strontium isotope geochemistry are presented as follows: 1) paleooceanographic temperaure reconstruction based on δ88/86 Sr of cold-water corals; 2) combining radiogenic strontium and stable strontium fractionation to study geochemical cycling in the ocean; and 3) paleodietary research with stable strontium in bones.