Palladium-Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine-Containing Molecules at Room Temperature

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• 作者：Riyadh Ahmed Atto Al-Shuaeeb ; Dr. Sergii Kolodych ; Dr. Oleksandr Koniev ; Dr. S&#233 ; bastien Delacroix ; St&#233 ; phane Erb ; St&#233 ; phanie Nicolaÿ ; Dr. Jean-Christophe Cintrat ; Prof. Jean-Daniel Brion ; Dr. Sarah Cianf&#233 ; rani ; Dr. Mouâ ; d Alami ; Dr. Alain Wagner and Dr. Samir Messaoudi
• 刊名：Chemistry - A European Journal
• 出版年：2016
• 出版时间：August 1, 2016
• 年：2016
• 卷：22
• 期：32
• 页码：11365-11370
• 全文大小：1721K
• ISSN：1521-3765

文摘

The third generation of aminobiphenyl palladacycle pre-catalyst “G3-Xantphos” enables functionalization of peptides containing cysteine in high yields. The conjugation (bioconjugation) occurs chemoselectively at room temperature under biocompatible conditions. Extension of the method to protein functionalization allows selective bioconjugation of the trastuzumab antibody.