Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazole-2(3H)-thione and Azidomethanone Derivatives Based on Quinoline-4-carbohydrazide Derivatives

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• 作者：Mansoura I. Mohamed ; Nadia G. Kandile and Howida T. Zaky
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：35-43
• 全文大小：365K
• ISSN：1943-5193

文摘

A new series compounds of quinoline derivatives were synthesized by reaction of 3-(carboxymethyl)-2-arylquinoline-4-carboxylic acids href="#jhet2529-eo-0002" rel="references:#jhet2529-eo-0002 #jhet2529-eo-0003 #jhet2529-eo-0004"> with different nucleophiles. The structures of the new compounds were elucidated on the basis of FTIR, ¹H-NMR, ¹³C-NMR spectral data, GC/MS, and chemical analysis. Investigation of antimicrobial activity of all new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration count against four pathogenic bacteria and two pathogenic fungi. Most of the new compounds were significantly active against bacteria and fungi.