Access to 2-Arylindoles via Decarboxylative C−C Coupling in Aqueous Medium and to Heteroaryl Carboxylates under Base-Free Conditions using Diaryliodonium Salts

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• 作者：Velladurai Arun ; Meenakshi Pilania and Prof. Dalip Kumar
• 刊名：Chemistry – An Asian Journal
• 出版年：2016
• 出版时间：December 6, 2016
• 年：2016
• 卷：11
• 期：23
• 页码：3345-3349
• 全文大小：1008K
• ISSN：1861-471X

文摘

Easily accessible heteroaromatic carboxylic acids and diaryliodonium salts were successfully employed to construct valuable 2-arylindoles and heteroaryl carboxylates in a regioselective fashion. C2-arylated indoles were produced using a Pd-catalyzed decarboxylative strategy in water without any base, oxidant, or ligand. Heteroaryl carboxylates were prepared under metal and base-free conditions. This protocol was successfully utilized to synthesize Paullone, a cyclin-dependent kinase (CDK) inhibitor.