Cadmium induces mucin 8 expression via Toll-like receptor 4-mediated extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells

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• 作者：Si-Youn Song ; Chang Hoon Bae ; Yoon Seok Choi and Yong-Dae Kim
• 刊名：International Forum of Allergy & Rhinology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：6
• 期：6
• 页码：638-645
• 全文大小：834K
• ISSN：2042-6984

文摘

Inhalation of cadmium can lead to development of inflammatory airway diseases such as acute pulmonary edema and chronic obstructive pulmonary disease. In inflammatory airway diseases, expression of mucins is increased, which leads to increased morbidity and mortality of the affected patients. However, no study on the effect of cadmium on expression of mucin genes in airway epithelial cells has been reported. Therefore, this study was conducted in order to investigate the effect and the brief signaling pathway of cadmium on expression of mucin genes in human airway epithelial cells.