Histopathologic and mutational analysis of a case of blue nevus-like melanoma

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• 作者：Julia Dai ; Michael T. Tetzlaff ; Lynn M. Schuchter ; David E. Elder and Rosalie Elenitsas
• 刊名：Journal of Cutaneous Pathology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：43
• 期：9
• 页码：776-780
• 全文大小：1092K
• ISSN：1600-0560

文摘

Blue nevi are a heterogeneous group of dermal melanocytic proliferations that share a common clinical appearance but remain controversial in their histopathologic and biologic distinction. While common blue nevi and cellular blue nevi are well-defined entities that are classified without significant controversy, the distinction between atypical cellular blue nevi and blue nevus-like melanoma remains diagnostically challenging. We report a case of a 46-year-old female with recurrent blue nevus-like melanoma of the scalp with liver metastases; mutational analysis showed GNA11 Q209L and BAP1 Q393 mutations. To our knowledge, this is the first case of blue nevus-like melanoma with GNA11 and BAP1 mutations. These particular mutations and the predilection for liver metastases in our patient's case underscore a fundamental biological relationship between blue nevi and uveal melanoma and suggest the two entities may prove amenable to similar diagnostic and prognostic testing and targeted therapies