The placebo response of injectable GLP-1 receptor agonists vs. oral DPP-4 inhibitors and SGLT-2 inhibitors: a systematic review and meta-analysis

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• 作者：Helena M. de Wit ; Maarten te Groen ; Maroeska M. Rovers and Cees J. Tack
• 刊名：British Journal of Clinical Pharmacology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：82
• 期：1
• 页码：301-314
• 全文大小：1846K
• ISSN：1365-2125

文摘

The size of the placebo response in type 2 diabetes (T2DM) treatment and its relation to the route of drug administration have not been systematically reviewed. We aimed to determine weight loss, change in HbA1c and incidence of adverse events after treatment with injectable placebo GLP-1 receptor agonist (GLP-1ra), compared with oral placebo DPP-4 inhibitor (DPP-4i) and placebo SGLT-2 inhibitor (SGLT-2i).