The cover picture shows competitive inhibition of the cytochrome
c/cytochrome
c peroxidase interaction by highly functionalized ruthenium(II) tris(bipyridine) complexes. Inhibition is achieved through recognition of the solvent-exposed surface of cytochrome
c using ruthenium(II) tris(bipyridine) complexes at the cytochrome
c peroxidase binding site, as shown by 950 MHz natural-abundance NMR spectroscopy and detailed fluorescence studies. Binding is driven by entropy and electrostatic effects with additional potency arising in higher-affinity complexes from enthalpic contributions. More information can be found in the full paper by A. J. Wilson et al.
page 223 in Issue 2, 2017 (DOI:
10.1002/cbic.201600552).