Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts

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• 作者：Megan S. Lord ; Brooke L. Farrugia ; Claudia M. Y. Yan ; James A. Vassie and John M. Whitelock
• 刊名：Journal of Biomedical Materials Research Part A
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：104
• 期：7
• 页码：1736-1746
• 全文大小：824K
• ISSN：1552-4965

文摘

Cerium oxide nanoparticles are being widely explored for cell therapies. In this study, nanoceria was functionalized with hyaluronan (HA) using the organosilane linker, 3-aminopropyltriethoxysilane. HA-nanoceria was found to be cytocompatible and to reduce intracellular reactive oxygen species in human fibroblasts. The HA-nanoceria was found to colocalize with CD44 on the surface of the cells and once internalized traffic to the lysosomes, be degraded and induce markers of autophagy. These particles were also effective in reducing the cell surface expression of CD44. Together these data suggest that HA-nanoceria is a promising drug delivery material to target CD44-expressing cells through a variety of mechanisms.