ChemInform Abstract: Nucleophilic Substitution Reaction of Pyrimidin-2-yl Phosphates Using Amines and Thiols as Nucleophiles Mediated by PEG-400 as an Environmentally Friendly Solvent.
A simple, rapid and environmentally benign procedure for the synthesis of C-2 substituted pyrimidines under catalyst-, base-, and ligand-free conditions is developed.