Superfluorinated PEI Derivative Coupled with 99mTc for ASGPR Targeted 19F MRI/SPECT/PA Tri-Modality Imaging

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• 作者：Zhide Guo ; Mengna Gao ; Manli Song ; Yesen Li ; Deliang Zhang ; Duo Xu ; Linyi You ; Liangliang Wang ; Rongqiang Zhuang ; Xinhui Su ; Ting Liu ; Jin Du and Xianzhong Zhang
• 刊名：Advanced Materials
• 出版年：2016
• 出版时间：July 27, 2016
• 年：2016
• 卷：28
• 期：28
• 页码：5898-5906
• 全文大小：6386K
• ISSN：1521-4095

文摘

Fluorinated polyethylenimine derivative labeled with radionuclide ^99mTc is developed as a ¹⁹F MRI/SPECT/PA multifunctional imaging agent with good asialoglycoprotein receptors (ASGPR)-targeting ability. This multifunctional agent is safe and suitable for ¹⁹F MRI/SPECT/PA imaging and has the potential to detect hepatic diseases and to assess liver function, which provide powerful support for the development of personalized and precision medicine.