Cyclosporin a induces renal episodic hypoxia

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• 作者：M. Fä ; hling ; S. Mathia ; J. Scheidl ; R. Abramovitch ; Z. Milman ; A. Paliege ; H. Peters ; P. B. Persson ; S. N. Heyman and C. Rosenberger
• 刊名：Acta Physiologica
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：219
• 期：3
• 页码：625-639
• 全文大小：2582K
• ISSN：1748-1716

文摘

Cyclosporin A (CsA) causes renal toxicity. The underlying mechanisms are incompletely understood, but may involve renal hypoxia and hypoxia-inducible factors (Hifs). We sought for hypoxia and Hif in mouse kidneys with CsA-induced toxicity, assessed their time course, Hif-mediated responses and the impact of interventional Hif upregulation.