文摘
A new type of tumor-targeted nanovehicle (PSPGP) is successfully synthesized for co-delivery of PTX (paclitaxel) and TR3 siRNA, by G. Yu, G. Tang, and co-workers in article number 1602697. In vitro and in vivo investigations demonstrate that the redox-responsive PSPGP exhibited enhanced endosomal escape and intracellular degradation, which facilitates PTX and TR3 siRNA release, effectively improving the anti-tumor efficacy.