MR-based measurements and simulations of the magnetic field created by a realistic transcranial magnetic stimulation (TMS) coil and stimulator

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• 作者：Stefano Mandija ; Petar I. Petrov ; Sebastian F.W. Neggers ; Peter R. Luijten and Cornelis A.T. van den Berg
• 刊名：NMR in Biomedicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：29
• 期：11
• 页码：1590-1600
• 全文大小：1320K
• ISSN：1099-1492

文摘

Transcranial magnetic stimulation (TMS) is an emerging technique that allows non-invasive neurostimulation. However, the correct validation of electromagnetic models of typical TMS coils and the correct assessment of the incident TMS field (B_TMS) produced by standard TMS stimulators are still lacking. Such a validation can be performed by mapping B_TMS produced by a realistic TMS setup. In this study, we show that MRI can provide precise quantification of the magnetic field produced by a realistic TMS coil and a clinically used TMS stimulator in the region in which neurostimulation occurs. Measurements of the phase accumulation created by TMS pulses applied during a tailored MR sequence were performed in a phantom. Dedicated hardware was developed to synchronize a typical, clinically used, TMS setup with a 3-T MR scanner. For comparison purposes, electromagnetic simulations of B_TMS were performed. MR-based measurements allow the mapping and quantification of B_TMS starting 2.5 cm from the TMS coil. For closer regions, the intra-voxel dephasing induced by B_TMS prohibits TMS field measurements. For 1% TMS output, the maximum measured value was ~0.1 mT. Simulations reflect quantitatively the experimental data. These measurements can be used to validate electromagnetic models of TMS coils, to guide TMS coil positioning, and for dosimetry and quality assessment of concurrent TMS-MRI studies without the need for crude methods, such as motor threshold, for stimulation dose determination.