Ruthenium-Catalyzed C−H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides
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- 作者：Dr. Marco Simonetti ; Diego M. Cannas ; Adyasha Panigrahi ; Dr. Szymon Kujawa ; Dr. Michal Kryjewski ; Dr. Pan Xie and Prof. Igor Larrosa
- 刊名：Chemistry - A European Journal
- 出版年：2017
- 出版时间：January 12, 2017
- 年：2017
- 卷：23
- 期：3
- 页码：549-553
- 全文大小：1939K
- ISSN：1521-3765
文摘
Herein we report the first Ru-catalyzed C−H arylation of benzoic acids with readily available aryl (pseudo)halides. The reaction, which does not require the use of silver salt additives, allows the arylation of previously challenging hindered benzoic acids and the use of generally unreactive ortho-substituted halorarenes. Furthermore, our new protocol can efficiently be applied to indole carboxylic acids, thus allowing access to C7-, C6-, C5- and C4-arylated indole compounds, a departure from the classical enhanced reactivity of the C2 and C3 positions of indole.