Three-Component Povarov Reaction with Alcohols as Alkene Precursors: Efficient Access to 2-Arylquinolines
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- 作者：Xinjian Li ; Qi Xing ; Pan Li ; Jingjing Zhao and Fuwei Li
- 刊名：European Journal of Organic Chemistry
- 出版年：2017
- 出版时间：January 18, 2017
- 年：2017
- 卷：2017
- 期：3
- 页码：618-625
- 全文大小：1285K
- ISSN：1099-0690
文摘
An atom-economic and efficient approach to the synthesis of 2-arylquinolines has been developed. The protocol involves an iron-catalysed cascade N-alkylation/aerobic oxidation/Povarov reaction, and the desired quinolines were prepared in moderate to excellent yields from readily accessible anilines, aldehydes, and EtOH/nPrOH, with water as the only side-product. The aniline substrates also act as a recyclable transfer medium for EtOH/nPrOH through an in-situ N-alkylation/oxidation process. This makes EtOH/nPrOH an economical and environmentally friendly precursor of alkenes as well as the solvent.