Thirty years of phase I radiochemotherapy trials: Latest development
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- 作者：Romain Rivoirarda ; Alexis Vallardb ; Julien Langrand-Escureb ; Majed Ben Mradb ; Guoping Wangb ; Jean-Baptiste Guyb ; Peng Diaob ; Alexandre Dubanchetb ; Eric Deutschc ; Chloe Rancouleb ; Nicolas Magneb ; nicolas.magne@icloire.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Concomitant radiochemotherapy ; Dose escalation ; Maximum tolerated dose ; Clinical trials ; phase I as topic ; Research design ; Review ; Targeted therapies
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：1-7
- 全文大小：374 K
文摘
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228 studies of early radiochemotherapy trials were published in the last 30 years.
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Half of studies were performed after 2010 but concerned classical chemotherapies.
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Radiochemotherapy trials mainly concerned head and neck, lung and brain cancers.
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Classical methodology seems unsuitable regarding large combination's possibilities.