Gelsochalotine, a novel indole ring-degraded monoterpenoid indole alkaloid from Gelsemium elegans

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• 作者：Shuang Liang^a ; ^{ls7312@163.com} ; Chun-Yong He^a ; Lá ; szló ; F. Szabó ; ^b ; ^? ; Yi Feng^a ; ^{fyi@vip.sina.com} ; Xiao Lin^a ; Yuan Wang^a
• 关键词：Indole alkaloid ; Gelsochalotine ; Gelsemium elegans Benth.
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：20 February, 2013
• 年：2013
• 卷：54
• 期：8
• 页码：887-890
• 全文大小：426 K

文摘

A phytochemical investigation of Gelsemium elegans Benth. led to the isolation of a novel alkaloid, gelsochalotine (ldFont"">1), as the first example of an indole ring-degraded monoterpenoid indole alkaloid from the family Loganiaceae. The structure of ldFont"">1 was elucidated by spectroscopic analysis, and confirmed by single crystal X-ray diffraction. Studies on the biogenetic derivation of ldFont"">1 were performed and its cytotoxic activities against human cancer cell lines, BEL-7420 and MDA-MD-435 cell, were evaluated with the MTT assay.