HIV-1 transgenic rats develop T cell abnormalities

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• 作者：Reid ; William ; Abdelwahab ; Sayed ; Sadowska ; Mariola ; Huso ; David ; Neal ; Ashley ; Ahearn ; Aaron ; et. al.
• 关键词：Th1/Th2 cells ; HIV-1 ; Transgenic ; Th ; helper CD4 T Cell ; Tc ; helper CD8 T Cells ; HIV ; human immunodeficiency virus ; Tg ; transgenic
• 刊名：Virology
• 出版年：2004
• 出版时间：March 30, 2004
• 年：2004
• 卷：321
• 期：1
• 页码：111-119
• 全文大小：474 K

文摘

HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4⁺ and CD8⁺ T cells able to produce IFN-γ following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4⁺ and CD8⁺ effector/memory (CD45RC⁻CD62L⁻) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC⁺CD62L⁺) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.