Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisons

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• 作者：Sharyn L. Rossi^a ; ¹ ; Casey J. Lumpkin^a ; ^e ; ¹ ; Ashlee W. Harris^a ; ¹ ; Jennifer Holbrook^c ; Cinsley Gentillon^a ; ^e ; Suzanne M. McCahan^b ; ^d ; ^f ; Wenlan Wang^a ; ^b ; ^&dagger ; ; Matthew E.R. Butchbach^a ; ^b ; ^e ; ^f ; ^{butchbach@nemoursresearch.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Motor neuron ; Cortical neuron ; Camptothecin ; Actinomycin D ; β-lapachone ; DNA damage response ; Immediate early gene ; Microarray ; Dyrk3
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2016
• 出版时间：14 October 2016
• 年：2016
• 卷：479
• 期：2
• 页码：319-324
• 全文大小：772 K

文摘

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d="p0010">Cultured neurons are more sensitive than fibroblasts to camptothecin and actinomycin D toxicity.

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d="p0015">Topoisomerase I mRNA levels are higher in neurons than in fibroblasts.

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d="p0020">Camptothecin increases Egr-1, Gadd45b and Dyrk3 in neurons but not fibroblasts.

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