Oxidative stress plays major role in mediating apoptosis in filarial nematode Setaria cervi in the presence of trans-stilbene derivatives
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- 作者：Niladri Mukherjeea ; Pravat Kumar Paridab ; Abhishek Santrab ; Tamashree Ghoshb ; Ananya Duttab ; Kuladip Janab ; 1 ; kuladip.jana@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Anup Kumar Misrab ; 1 ; akmisra69@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Santi P. Sinha Babua ; 1 ; spsinhababu@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apaf ; apoptotic protease activating factor ; BCl-2 ; B-cell lymphoma 2 ; CED ; cell-death abnormal ; CM ; culture media ; DEC ; diethyl-carbamazine citrate ; DMSO ; dimethyl sulfoxide ; EGL ; egg laying defective ; EtBr ; ethidium bromide ; FBS ; fetal bovine serum ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; GSH ; glutathione ; GPx ; glutathione peroxidase ; GR ; glutathione reductase ; GST ; glutathione-S-transferase ; mf ; microfilariae ; JC-1 ; 5 ; 5&prime ; 6 ; 6&prime ; -tetrachloro-1 ; 1&prime ; 3 ; 3&prime ; -tetraethylben
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：130-144
- 全文大小：4943 K
文摘
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Naturally abundant polyphenols were evaluated for their anti-filarial activities.
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10">Anti-filarial activities of synthesized trans-stilbene derivatives were evaluated.
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15">Trans-stilbene derivatives induce caspase-mediated apoptosis in S. cervi filaria.
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ROS induced apoptotic death of the treated filarial parasites was observed.
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These compounds can potentiate new therapeutics against bancroftian filariasis.