Early Results of Core Decompression and Autologous Bone Marrow Mononuclear Cells Instillation in Femoral Head Osteonecrosis: A Randomized Control Study

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• 作者：Ramesh Kumar Sen ; MS ; DNB ; PhD^?/sup> ; ; Sujit Kumar Tripathy ; DNB ; Dip SICOT ; MNAMS^?/sup> ; Sameer Aggarwal ; MS^?/sup> ; Neelam Marwaha ; MD^&dagger ; ; Ratti Ram Sharma ; MD^&dagger ; ; Niranjan Khandelwal ; MD^&Dagger ;
• 关键词：avascular necrosis ; bone marrow mononuclear cell ; core decompression ; osteonecrosis ; femoral head ; stem cell
• 刊名：The Journal of Arthroplasty
• 出版年：2012
• 出版时间：May, 2012
• 年：2012
• 卷：27
• 期：5
• 页码：679-686
• 全文大小：765 K

文摘

Fifty-one osteonecrotic hips in 40 patients were randomly divided into 2 treatment groups. Patients in group A (25 hips) were treated with core decompression, and those in group B (26 hips) received autologous bone marrow mononuclear cell instillation into the core tract after core decompression. Outcome between the 2 groups were compared clinically (Harris Hip score), radiographically (x-ray and magnetic resonance imaging), and by Kaplan-Meier hip survival analysis after 12 and 24 months of surgical intervention. The clinical score and mean hip survival were significantly better in group B than in group A (P < .05). Patients with adverse prognostic features at initial presentation, that is, poor Harris Hip score, x-ray changes, edema, and/or effusion on magnetic resonance imaging had significantly better clinical outcome and hip survival in group B than in group A.