Neurodevelopmental damage after prenatal infection: Role of oxidative stress in the fetal brain
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- 作者：Fabien Lanté ; Johann Meunier ; Janique Guiram ; Tangui Maurice ; Mé ; lanie Cavalier ; Marie-Cé ; leste de Jesus Ferreira ; Rose Aimar ; Catherine Cohen-Solal ; Michel Vignes ; Gé ; rard Barbanel
- 关键词：LPS ; Prenatal stress ; Protein carbonylation ; α ; -Tocopherol ; N-Acetylcysteine ; Long-term potentiation ; Spatial memory ; NMDA receptor ; Hippocampus ; Rat ; Free radicals
- 刊名：Free Radical Biology and Medicine
- 出版年：2007
- 出版时间：15 April 2007
- 年：2007
- 卷：42
- 期：8
- 页码：1231-1245
- 全文大小：759 K
文摘
Prenatal infection is a major risk responsible for the occurrence of psychiatric conditions in infants. Mimicking maternal infection by exposing pregnant rodents to bacterial endotoxin lipopolysaccharide (LPS) also leads to major brain disorders in the offspring. The mechanisms of LPS action remain, however, unknown. Here, we show that LPS injection during pregnancy in rats, 2 days before delivery, triggered an oxidative stress in the hippocampus of male fetuses, evidenced by a rapid rise in protein carbonylation and by decreases in α-tocopherol levels and in the ratio of reduced/oxidized forms of glutathione (GSH/GSSG). Neither protein carbonylation increase nor decreases in α-tocopherol levels and GSH/GSSG ratio were observed in female fetuses. NMDA synaptic currents and long-term potentiation in CA1, as well as spatial recognition in the water maze, were also impaired in male but not in female 28-day-old offspring. Pretreatment with the antioxidant N-acetylcysteine prevented the LPS-induced changes in the biochemical markers of oxidative stress in male fetuses, and the delayed detrimental effects in male 28-day-old offspring, completely restoring both long-term potentiation in the hippocampus and spatial recognition performance. Oxidative stress in the hippocampus of male fetuses may thus participate in the neurodevelopmental damage induced by a prenatal LPS challenge.