Assay of ertapenem in human serum by high-performance liquid chromatography

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• 作者：Mehnam Soltani ; Alasdair P. MacGowan and Andrew M. Lovering
• 关键词：Assay ; Ertapenem ; HPLC ; Serum
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2006
• 出版时间：February 2006
• 年：2006
• 卷：27
• 期：2
• 页码：165-167
• 全文大小：75 K

文摘

Ertapenem is a new carbapenem with a broad spectrum of activity and an extended half-life, permitting once daily administration. Although high-performance liquid chromatography (HPLC) methods have been described for ertapenem, these are complex and involve column switching and thus this type of assay may not suitable for use in routine clinical microbiology laboratories. In this study we report a rapid, straightforward HPLC method for the detection of ertapenem in human serum.