Molecular predictive factors of response to anti-EGFR antibodies in colorectal cancer patients

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• 作者：Daniele Santini ; Francesco Pantano ; Bruno Vincenzi ; Fotios Loupakis ; Michele Caraglia ; Alfredo Falcone ; Giuseppe Tonini
• 关键词：EGFR ; Colorectal cancer ; Monoclonal antibodies ; Predictive ; Pharmacogenomic
• 刊名：European Journal of Cancer Supplements
• 出版年：2008
• 出版时间：October 2008
• 年：2008
• 卷：6
• 期：14
• 页码：86-90
• 全文大小：123 K

文摘

Monoclonal antibodies against EGFR represent one of the most important recent advancements in the treatment of colorectal cancer. Anyway, to date, only a subset of patients can really take advantage from this kind of drugs. The identification of predictive factors that are able to stratify patients who potentially can benefit by these biological treatment, is an important aim of anticancer research both in clinical and in pre-clinical fields. Many studies evaluating classical IHC analysis of protein expression failed in this purpose. So in the last years there was the need to look forward to a new class of molecular predictive factors. Indeed a number of biomarkers have been evaluated in their potential to predict the response to anti-EGFR-based therapies. These include marker related to EGFR amplification, activation and phosphorylation, EGFR polymorphisms, but also markers related to Ras/Raf/MAPK and the PI3K/Akt signalling pathways and angiogenesis. This review will focus the attention to these new genetic and molecular markers.