Studies on the mechanism of quaternization of the catharanthine part of vinblastine and vincristine
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- 作者：Pé ; ter Keglevicha ; Pé ; ter Á ; brá ; nyi-Baloghb ; Á ; ron Szigetvá ; ric ; Csaba Szá ; ntay Jr.c ; Csaba Szá ; ntaya ; Lá ; szló ; Hazaia ; hazai@mail.bme.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vinca alkaloids ; Vinblastine ; Quaternization ; Reaction mechanism ; DFT calculations
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：13 April 2016
- 年：2016
- 卷：57
- 期：15
- 页码：1672-1677
- 全文大小：1231 K
文摘
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Unexpected N-methylation in the Simmons–Smith reaction of vinblastine.
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First computed detailed mechanism on the Simmons–Smith reaction in a complex system.
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Energetic and mechanistic background for chemo- and regioselectivity.
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Experimental and DFT study for proving the reaction mechanism.