Galanthamine from snowdrop—the development of a modern drug against Alzheimer’s disease from local Caucasian knowledge
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- 作者：Heinrich ; Michael ; Lee Teoh ; Hooi
- 关键词：ACh ; acetylcholine ; AChE ; acetylcholinesterase ; AChEI ; acetylcholinesterase inhibitor ; AD ; Alzheimer’ ; s disease ; ADAS-cog/13 ; Alzheimer’ ; s Disease Assessment Scale&mdash ; cognitive subscale 13-item ; ADCS-ADL ; Alzheimer’ ; s Disease Cooperative St
- 刊名：Journal of Ethnopharmacology
- 出版年：2004
- 出版时间：June, 2004
- 年：2004
- 卷：92
- 期：2-3
- 页码：147-162
- 全文大小：169 K
文摘
In recent years, galanthamine isolated from several members of the Amaryllidaceae (Leucojum spp., Narcissus species, Galanthus spp.) has become an important therapeutic options used to slow down the process of neurological degeneration in Alzheimer’s disease. This review traces aspects of the history of its development from little known observational studies in the Caucasus Mountains (Southern Russia), to the use of this drug in Eastern European countries (esp. Bulgaria) in the treatment of poliomyelitis and ultimately to the recent introduction onto Western markets in the treatment of Alzheimer’s disease. Of note, little is known about the early history of the drug’s development and the review also points to other gaps in our knowledge about the ethnopharmacology, pharmacology and clinical use of galanthamine.