Modification of oral dosage forms for the older adult: An Irish prevalence study

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• 作者：Aoife Mc Gillicuddy^a ; ^{a.mcgillicuddy@umail.ucc.ie" class="auth_mail" title="E-mail the corresponding author} ; Maria Kelly^a ; Catherine Sweeney^b ; ^c ; Ann Carmichael^c ; Abina M. Crean^d ; Laura J. Sahm^a ; ^e
• 关键词：Oral dosage form modification ; Older patients ; Fractional dosing ; Medication administration ; Dysphagia
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：20 August 2016
• 年：2016
• 卷：510
• 期：1
• 页码：386-393
• 全文大小：593 K

文摘

Age-related pharmacological changes complicate oral dosage form (ODF) suitability for older adults. The aim of this study was to investigate the appropriateness of ODF for older adults by determining the prevalence of ODF modifications in an aged care facility in Ireland. Drug charts for eligible patients were obtained. Details of all medications administered were recorded. ODF modifications were examined to determine if they were evidence-based: defined as complying with the product license or best practice guidelines (BPG).

In total, of 111 patients, 35.1% received at least one modified medicine. Medicines were most commonly modified to facilitate fractional dosing (82.0%). Of the 68 instances of medicine modification, 35.3% complied with the product license. Of the 44 unlicensed modifications, 14 complied with BPG. Therefore, 44.1% of modifications were not evidence-based. This study highlights that clinicians have to routinely tailor commercial ODF to meet older patients’ needs despite the lack of an evidence-base for almost half of these modifications. The main factor contributing to these modifications is the lack of appropriate, licensed dosage forms. However, reimbursement policies also play a role. Research is needed to optimise medicine administration and to provide clinicians with much needed evidence to support their daily practice.