A strategy of designing the ligand of antibody affinity chromatography based on molecular dynamics simulation
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- 作者：Lu Daia ; Weikang Lib ; Fei Suna ; Baizhi Lia ; Hongrui Lia ; Hongxing Zhanga ; b ; zhanghx@mail.jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Qingchuan Zhengb ; zhengqc@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Chongyang Lianga ; liang@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Molecular dynamics ; Staphylococcal protein A ; Ligand ; Surface plasmon resonance
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：9 September 2016
- 年：2016
- 卷：1463
- 期：Complete
- 页码：81-89
- 全文大小：2075 K
文摘
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A new strategy to design ligand of antibody affinity media by MD simulation.
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Bioinformatics, Genetic Engineering and SPR test form the new strategy.
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A tetramer of SpA domain D mutant exerted higher binding ability in SPR test.