A monoclonal antibody that targets the conserved core/lipid A region of lipopolysaccharide affects motility and reduces intestinal colonization of both classical and El Tor Vibrio cholerae biotypes
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- 作者：Kara J. Levinson ; Danielle E. Baranova ; Nicholas J. Mantis ; nicholas.mantis@health.ny.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cholera ; Mucosal ; Immunity ; Vaccine ; Colonization
- 刊名：Vaccine
- 出版年：2016
- 出版时间：21 November 2016
- 年：2016
- 卷：34
- 期：48
- 页码：5833-5836
- 全文大小：539 K
文摘
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ZAC-3 is a monoclonal antibody against a conserved Vibrio cholerae epitope.
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ZAC-3 is an inhibitor of V. cholerae flagellum-based motility.
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ZAC-3 IgG and Fab fragments reduce V. cholerae intestinal colonization in a mouse model.
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ZAC-3 reveals potential of antibodies to confer immunity across V. cholerae biotypes.