AlloRep: A Repository of Sequence, Structural and Mutagenesis Data for the LacI/GalR Transcription Regulators
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- 作者：Filipa L. Sousa1 ; Daniel J. Parente2 ; 1 ; David L. Shis3 ; Jacob A. Hessman2 ; 1 ; Allen Chazelle2 ; Matthew R. Bennett3 ; 4 ; Sarah A. Teichmann5 ; 6 ; Liskin Swint-Kruse2 ; lswint-kruse@kumc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：transcription regulation ; variant database ; sequence alignment ; contact map ; allostery
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：22 February 2016
- 年：2016
- 卷：428
- 期：4
- 页码：671-678
- 全文大小：817 K
文摘
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AlloRep compiles sequence, mutagenesis, and structural data for LacI/GalR proteins.
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Alignments for > 3000 sequences are grouped by subfamily and sampled in the whole family alignment.
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AlloRep includes detailed phenotypic and biochemical data on almost 6000 variants.
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Structural data for 65 proteins are available as residue contact networks.
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A predicted allosteric position was validated by altering a synthetic repressor.