Weight restoration therapy rapidly reverses cortical thinning in anorexia nervosa: A longitudinal study
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- 作者：Fabio Bernardonia ; 1 ; Joseph A. Kinga ; 1 ; Daniel Geislera ; Elisa Steina ; Charlotte Jaiteb ; Dagmar Nä ; tscha ; Friederike I. Tama ; Ilka Boehma ; Maria Seidela ; Veit Roessnera ; Stefan Ehrlicha ; c ; d ; transden.lab@uniklinikum.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anorexia nervosa ; Cerebral cortex ; Cortical thickness ; FreeSurfer ; Structural MRI ; Subcortical structures ; Longitudinal
- 刊名：NeuroImage
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：214-222
- 全文大小：1381 K
文摘
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First longitudinal study of cortical thickness in anorexia nervosa.
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Cortical thinning in young patients is reversed by brief weight restoration therapy.
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Regionally unspecific thinning is rapidly normalized relative to healthy controls.
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Normalization was driven by weight gain but not by symptoms or illness duration.
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Rapid changes may reflect neuronal/glial remodeling but not neurogenesis.