The aim of this work is to present the integration of a simple and yet efficient dynamic muscle fatigue model in a multibody formulation with natural coordinates. The fatigue model considers the force production history of each muscle to estimate its fitness level by means of a three-compartment theory approach. The model is easily adapted to co-operate with standard Hill-type muscle models, allowing the simulation and analysis of the redundant muscle forces generated in the presence of muscular fatigue. This has particular relevance in the design of orthotic devices to support human locomotion and manipulation.