Synthesis of 6-chloro-2-Aryl-1H-imidazo[4,5-b]pyridine derivatives: Antidiabetic, antioxidant, β-glucuronidase inhibiton and their molecular docking studies
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- 作者：Muhammad Tahaa ; b ; taha_hej@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; muhamm9000@puncakalam.uitm.edu.my" class="auth_mail" title="E-mail the corresponding author ; Nor Hadiani Ismaila ; b ; Syahrul Imrana ; b ; Hesham Rashwanc ; Waqas Jamild ; Sajjad Alie ; Syed Muhammad Kashifd ; Fazal Rahimg ; Uzma Salarf ; Khalid Mohammed Khanf
- 关键词：6-Chloro-2-Aryl-1H-imidazo[4 ; 5-b]pyridine ; Spectroscopy ; Antiglycation ; Anti-oxidant ; β-Glucuronidase
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：48-56
- 全文大小：2569 K
文摘
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Synthesis of 1–26 6-chloro-2-Aryl-1H-imidazo[4,5-b]pyridine.
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In-vitro antioxidant, antiglycation, and β-glucuronidase inhibitory activity.
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Docking studies were carried out to confirm binding of active compounds with enzyme.