Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway
BME showed biphasic dose response to OGD-induced injury in PC12 cells. BME activated ERK and Akt under both OGD and normal condition. BME depressed OGD-induced mitochondrial apoptosis via activation of Nrf2/HO-1.