HCMV GrAbs a Mechanism to Escape Neutralization

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• 作者：Roselyn  ; J. Eisenberg¹ ;   ; ² ;   ; ^{roselyn@dental.upenn.edu} ; Tina  ; M. Cairns¹ ;   ; ² ; Gary  ; H. Cohen¹ ;   ; ²
• 刊名：Cell Host Microbe
• 出版年：2011
• 出版时间：15 September 2011
• 年：2011
• 卷：10
• 期：3
• 页码：177-178
• 全文大小：67 K

文摘

The HCMV-neutralizing monoclonal antibody MSL-109 failed to prevent HCMV-induced disease in the clinic. In this issue of mlns="""">Cell Host & Microbe, found that MSL-109 rapidly induces antibody resistance by a nongenetic mechanism. Their results shed light on how antibodies can interact with their targets both outside and inside infected cells and virions.