PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma
详细信息 查看全文
- 作者：Mirjam C. Boelens1 ; 5 ; Micha Nethe1 ; 5 ; Sjoerd Klarenbeek1 ; 5 ; Julian R. de Ruiter1 ; Eva Schut1 ; Nicola Bonzanni2 ; Amber L. Zeeman3 ; Ellen Wientjens1 ; Eline van der Burg1 ; Lodewyk Wessels2 ; René ; e van Amerongen3 ; Jos Jonkers1 ; 4 ; 6 ; j.jonkers@nki.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：breast cancer ; classical invasive lobular carcinoma ; genetically engineered mouse model ; Cre-lox ; E-cadherin ; PTEN ; metastasis ; tumor microenvironment ; BEZ235
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：23 August 2016
- 年：2016
- 卷：16
- 期：8
- 页码：2087-2101
- 全文大小：9404 K
文摘
- •
PTEN loss rescues apoptosis induced by E-cadherin loss in mouse mammary epithelium
- •
Combined loss of E-cadherin and PTEN is sufficient to cause mouse mammary tumors
- •
These mouse mammary tumors closely resemble human classical lobular carcinoma (CLC)
- •
Mouse CLCs induced by loss of E-cadherin and PTEN regress upon PI3K inhibition