Impact of obesity on bone metabolism

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• 作者：Juan J. L&oacute ; pez-G&oacute ; mez^a ; ^b ; ^{jjlopez161282@hotmail.com} ; José ; L. Pé ; rez Castrill&oacute ; n^b ; ^c ; Daniel A. de Luis Romá ; n^a ; ^b
• 关键词：Obesity ; Bone turnover ; Adypocytokines ; Vitamin D
• 刊名：Endocrinología y Nutrición (English Edition)
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：63
• 期：10
• 页码：551-559
• 全文大小：1054 K
• 卷排序：63

文摘

High weight is a protective factor against osteoporosis and risk of fracture. In obesity, however, where overweight is associated to excess fat, this relationship does not appear to be so clear, excess weight has sometimes been associated to decreased bone mass. Obesity interferes with bone metabolism through mechanical, hormonal, and inflammatory factors. These factors are closely related to weight, body composition, and dietary patterns of these patients. The net beneficial or harmful effect on bone mass or risk of fracture of the different components of this condition is not well known. We need to recognize patients at a greater risk of bone disease related to obesity to start an adequate intervention.