DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates
详细信息 查看全文
- 作者：Erik M.K. Rasmussena ; erik.rasmussen@nmbu.no" class="auth_mail" title="E-mail the corresponding author ; Cathrine B. Vå ; gbø ; b ; Daniel Mü ; ncha ; Hans E. Krokanb ; Arne Klunglandc ; Gro V. Amdama ; d ; John Arne Dahlc
- 关键词：Honey bee ; Fruit fly ; Demethylation ; 5-hydroxymethylcytosine
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：6
- 期：Complete
- 页码：9-15
- 全文大小：468 K
文摘
- bel">•
Reporting cytosine modifications in uncharacterized tissues, phenotypes and species.
- bel">•
Quantification of 5mC and 5hmC suggests species-specific roles and turnover.
- bel">•
Low levels of 5hmC relative to 5mC and cytosine in honey bees compared to mammals.
- bel">•
Honey bee abdominal tissues are richer in5hmC than the brain.
- bel">•
We found a higher 5hmC to 5mC ratio in fruit flies as compared to the honey bee.