CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly

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• 作者：Sebastian Hoffmann¹ ; ⁴ ; Marie Dumont¹ ; ⁴ ; Viviana Barra¹ ; Peter Ly² ; ³ ; Yael Nechemia-Arbely² ; ³ ; Moira A. McMahon² ; ³ ; Sol&egrave ; ne Herv&eacute ; ¹ ; Don W. Cleveland² ; ³ ; ^{dcleveland@ucsd.edu} ; Daniele Fachinetti¹ ; ⁵ ; ^{daniele.fachinetti@curie.fr}
• 关键词：mitosis ; centromere ; kinetochore ; chromosome segregation ; CENP-A ; CENP-B ; CENP-C ; epigenetic ; protein degradation ; auxin
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2394-2404
• 全文大小：3703 K
• 卷排序：17

文摘

Rapid and complete loss of endogenous human CENP-A using an auxin-inducible degron Kinetochore attachment to the centromere is maintained following loss of CENP-A After the initial steps of centromere assembly, CENP-A is dispensable for mitosis Faithful chromosome segregation by CENP-A-depleted kinetochores requires CENP-B