The contribution of lower vertebrate animal models in human reproduction research

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• 作者：Rosanna Chianese^a ; ¹ ; Teresa Chioccarelli^a ; ¹ ; Giovanna Cacciola^a ; ¹ ; Vincenza Ciaramella^a ; Silvia Fasano^a ; Riccardo Pierantoni^a ; ; ^{riccardo.pierantoni@unina2.it} ; Rosaria Meccariello^b ; ² ; Gilda Cobellis^a ; ²
• 关键词：Non-mammalian vertebrates ; Estrogens ; GnRH ; Endocannabinoid system ; Human reproduction
• 刊名：General and Comparative Endocrinology
• 出版年：2011
• 出版时间：1 March 2011
• 年：2011
• 卷：171
• 期：1
• 页码：17-27
• 全文大小：444 K

文摘

Many advances have been carried out on the estrogens, GnRH and endocannabinoid system that have impact in the reproductive field. Indeed, estrogens, the generally accepted female hormones, have performed an unsuspected role in male sexual functions thanks to studies on non-mammalian vertebrates. Similarly, these animal models have provided important contributions to the identification of several GnRH ligand and receptor variants and their possible involvement in sexual behavior and gonadal function regulation. Moreover, the use of non-mammalian animal models has contributed to a better comprehension about the endocannabinoid system action in several mammalian reproductive events. We wish to highlight here how non-mammalian vertebrate animal model research contributes to advancements with implications on human health as well as providing a phylogenetic perspective on the evolution of reproductive systems in vertebrates.