Chasing fate and function of new neurons in adult brains

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• 作者：Scharff ; Constance
• 关键词：Adult neurogenesis ; Song birds ; Neuronal fate ; Lineage ; Behaviour ; Hippocampus ; Cell death ; Laser ; Photolysis ; Insects
• 刊名：Current Opinion in Neurobiology
• 出版年：2000
• 出版时间：December 1, 2000
• 年：2000
• 卷：10
• 期：6
• 页码：774-783
• 全文大小：329 K

文摘

Neuron production, migration and differentiation are major developmental events that continue, on a smaller scale, into adult life in a wide range of species from insects to mammals. Recent reports of adult neurogenesis in primates, including humans, have led to explosive scientific and public attention. During the last two years, significant discoveries have revealed that the generation, recruitment and survival of new neurons in adult brains are governed by principles similar to those that shape the developing brain, such as neuronal death, sensory experience, activity levels, and learning. Similarly, many factors implicated in embryonic neurogenesis are increasingly found to regulate adult neurogenesis and survival as well. These findings now allow the first manipulations of the numbers of adult-generated neurons to address their potential behavioral function.