Polymer complex of CDDP with styrene-maleic acid-copolymer, SMA–CDDP was synthesized.
SMA–CDDP behaves as polymeric micelle with particle size of 102.5 nm.
Release of CDDP from SMA–CDDP exhibits pH-dependency: higher release at acidic pH.
SMA–CDDP showed 5-time higher tumor accumulation than free CDDP based on EPR effect.
Remarkable in vivo antitumor effect was achieved by SMA–CDDP with less side effect.