Pterostilbene exerts anti-neuroinflammatory effect on lipopolysaccharide-activated microglia via inhibition of MAPK signalling pathways
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- 作者：Yue Houa ; Ning Lib ; c ; liningsypharm@163.com" class="auth_mail" title="E-mail the corresponding author ; Guanbo Xied ; Jian Wangc ; e ; Qing Yuana ; Congcong Jiaa ; Xia Liua ; Guoxun Lia ; Yingzhan Tangb ; c ; Bing Wanga ; wangbing@mail.neu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pterostilbene (PubChem CID ; 5281727)
- 刊名：Journal of Functional Foods
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：19
- 期：part_PA
- 页码：676-687
- 全文大小：2342 K
文摘
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Pterostilbene inhibited MAPK signalling pathways and the level of pro-inflammatory mediators in LPS-activated microglia.
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The inhibitory effect of pterostilbene on neuroinflammation was confirmed in vivo by using a rat neuroinflammation model.
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Pterostilbene possessed neuroprotective anti-inflammatory property that may benefit neurodegenerative diseases.