p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells
详细信息 查看全文
- 作者：Atsushi Umemura1 ; 5 ; Feng He1 ; Koji Taniguchi1 ; 10 ; 11 ; Hayato Nakagawa1 ; 7 ; Shinichiro Yamachika1 ; Joan Font-Burgada1 ; Zhenyu Zhong1 ; Shankar Subramaniam3 ; Sindhu Raghunandan3 ; Angeles Duran9 ; Juan F. Linares9 ; Miguel Reina-Campos9 ; Shiori Umemura1 ; 6 ; Mark A. Valasek2 ; Ekihiro Seki4 ; 8 ; Kanji Yamaguchi5 ; Kazuhiko Koike7 ; Yoshito Itoh5 ; Maria T. Diaz-Meco9 ; Jorge Moscat9 ; jmoscat@sbpdiscovery.org" class="auth_mail" title="E-mail the corresponding author ; Michael Karin1 ; 2 ; karinoffice@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：13 June 2016
- 年：2016
- 卷：29
- 期：6
- 页码：935-948
- 全文大小：7051 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
p62 in preneoplastic lesions is important for HCC development regardless of etiology
- class="label">•
Ectopic p62 expression is sufficient for HCC induction in autophagy-competent liver
- class="label">•
p62 exerts its oncogenic activity via NRF2 and mTORC1 but not via ubiquitin binding
- class="label">•
p62 promotes survival and expansion of ROS-containing HCC-initiating cells