Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy
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- 作者：Tian Qina ; b ; 1 ; tim_chin@sina.com" class="auth_mail" title="E-mail the corresponding author ; Ronghui Dua ; 1 ; rhdu@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Fengjie Huangb ; 1 ; hfj@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shasha Yina ; sswwyql@163.com" class="auth_mail" title="E-mail the corresponding author ; Jun Yanga ; yangjuni0704@163.com" class="auth_mail" title="E-mail the corresponding author ; Siyuan Qina ; shfdmc2010@163.com" class="auth_mail" title="E-mail the corresponding author ; Wangsen Caoa ; wangsencao@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CKD ; Chronic kidney disease ; CRF ; Chronic renal failure ; RA ; Rheumatoid arthritis ; ON ; Obstructive nephropathy ; ROS ; Reactive oxygen species ; UUO ; Unilateral ureteral obstruction ; HE ; Hematoxylin and eosin ; SIN ; Sinomenine ; LPS ; Lipopolysaccharide ; 3-MA ; 3-methylamphetamine ; CQ ; Chloroquine ; TGF-β ; Transforming growth factor β ; Keap1 ; The Kelch-like ECH-associated protein 1 ; Nrf2 ; Nuclear factor-erythroid 2 (NF-E2)-related factor ; HO-1 ; Heme oxygenase-1 ; NQO1 ; NAD(P)H ; quinoneoxidoreductase 1 ; N
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：90-99
- 全文大小：4466 K
文摘
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SIN reduces inflammation, oxidative stress, and renal damage in UUO mice.
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SIN is an Nrf2 activator and it activates Nrf2 signaling through Keap1 degradation.
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SIN inhibits the M1 and promotes the M2 polarization in macrophages.
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SIN Nrf2-dependently relieves renal inflammation and NF-kB signaling.
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Nrf2 is essential for SIN functions in inflammation inhibition and renoprotection.